About topic

Raman spectroscopy is one of vibrational spectroscopy what used to investigate the composition of substances on a molecular basis. Although the application of Raman spectra always use for identified chemical components in the matter but the background of it is filled with the principal of electromagnetic in the material. Because of there is rapid, cost-effective, easy to operate, requires simple sample preparation and non-destructive technique so there widely used in many fields works such as detection of the explosive substance, body fluids analysis or verification of art age etc. However, Raman spectroscopy is technique what base on Raman scattering that has one in a million of all scattering so many techniques were developed for the Raman signal enhancement, the surface enhanced Raman spectroscopy is one of them which applied the nanostructure to elevation Raman signal.

Malaria is typically found in tropical and subtropical climates where the parasites can live. The World Health Organization (WHO) record, there are more than 100 million case of malaria per year. So it’s good for treatment if we can detect malaria as soon as possible. Nowadays PCR technique is operated to ensure Malaria infection in human spend much time for the result so the enhanced Raman spectroscopy may provide a new way for early Malaria detection.

Fundamental knowledge

  • Basic Electromagnetic theory
  • Principal of Raman spectroscopy surface enhanced Raman spectroscopy
  • Localized surface Plasmon resonance

Suggestion book and research

  • Chen F, et al, “Direct detection of malaria infected red blood cells by surface enhanced Raman spectroscopy.”Nanomedicine:NBM 2016
  • K M Kosuda, J M Bingham, K L Wustholz and R P Van Duyne (2011) Nanostructures and SurfaceEnhanced Raman Spectroscopy. In: Andrews DL, Scholes, GD and Wiederrecht GP (eds.), Comprehensive Nanoscience and Technology, volume 3, pp. 263301 Oxford: Academic Press.
  • Eric Le Ru,Pablo Etchegoin, Principle of surface enhanced Raman spectroscopy and related plasmonic effects
  • Rajapandiyan Panneerselvam,a Guo-Kun Liu, Yao-Hui Wang,c Jun-Yang Liu,a Song-Yuan Ding,a Jian-Feng Li, ac De-Yin Wu a and Zhong-Qun Tian , Surface-enhanced Raman spectroscopy: bottlenecks and future directions, The Royal Society of Chemistry 2018

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